Employing deep genomic sequencing to reveal the biological principles of neuroblastoma

Our lab is focused on elucidating the genetic etiology of neuroblastoma, a pediatric tumor of the sympathetic nervous system. We are using high-throughput technologies, such as next generation sequencing and microarray analysis, to examine the genomic and transcriptomic characteristics of clinical neuroblastoma subtypes. We also employ in vitro and in vivo neuroblastoma models to determine the mechanistic relevance of mutated cancer genes in tumor development and progression, and to assess their potential as therapeutic targets. All of our work is geared to translate novel findings from basic research into clinical practice, in order to improve clinical management of neuroblastoma patients.