The data provided by the Pasparakis lab indicate that the kinase RIPK1 cooperates with NF-κB signaling to prevent TNFR1-independent hepatocyte apoptosis and the development of chronic liver disease and cancer, but acts downstream of TNFR1 signaling to promote chemically-induced liver tumorigenesis. As part of the Else Kröner Forschungskolleg Cologne, Manolis Pasparakis provides innovative genetically-engineered mouse models of cancer, focusing on gastrointestinal malignancies and immune biology.