Manolis Pasparakis publishes his work on the role of RIPK1 in liver carcinogenesis

The Else Kröner Forschungskolleg Cologne principal investigator Manolis Pasparakis and his team published their work on RIPK1 and its role in liver carcinogenesis in the Journal of Clinical Investigation.

The data provided by the Pasparakis lab indicate that the kinase RIPK1 cooperates with NF-κB signaling to prevent TNFR1-independent hepatocyte apoptosis and the development of chronic liver disease and cancer, but acts downstream of TNFR1 signaling to promote chemically-induced liver tumorigenesis. As part of the Else Kröner Forschungskolleg Cologne, Manolis Pasparakis provides innovative genetically-engineered mouse models of cancer, focusing on gastrointestinal malignancies and immune biology.

Prof. Manolis Pasparakis