Dr. Christoph Arolt

Group: Prof. Dr. Axel Hilmer, Genomische Pathologie



Spatial transcriptomics of esophageal adenocarcinomas: understanding the role of tumor architecture for stroma activity and treatment resistance

One Fellow...Two Questions...

Christoph, what was your motivation of becoming an EKFS fellow?

After three years of clinical training and simultaneous research, I plan to commit more time to projects that provide deeper insights into mechanisms of TME.
Also, becoming acquainted to novel, elaborate technologies will require a stronger focus on research for a defined period of time. The EKFS provides both the freedom to achieve these goals and a distinguished scientific framework.

I am now looking forward to be part of an interdisciplinary group that is focused on ambitious oncologic results.

Where lie your clinical and scientific interests?

Having the opportunity to visualize, analyze and understand the architecture and driver mechanisms of tumors has been the major reason to start my training in pathology.
Clinically, I followed the path towards the complex subtyping of salivary gland carcinomas (SGC) both morphologically and through molecular testing.
Recently, for the first time, we described the extracellular matrix composition of SGC using Nanostring and IHC/ISH. More recently, my focus broadened towards a training in GI pathology.
Scientifically, my overarching interest is to identify the complex interactions of cells within the tissue microenvironment (TME) of carcinomas.

As a next step, I would like to extend my field of research towards the TME of esophageal adenocarcinomas.
I am convinced that we should invest in understanding the spacial dimension to highly-plexed genetic and proteomic analysis which will fuel the discovery of novel cellular interactions.